Yagub Fearnley, the English number three, came out after a flat defeat by top seed Alexander Zverev.
In addition to the plain sets in Australia, the German, which also beats Scott, for an hour, 6-2 6-4 needs to win 14 minutes.
Despite the defeat, Fearnley will rise above Cameron Norrie to be English Numbered English Number – ATP ratings are updated after Miami.
Elsewhere, Hong Kong, 20-year-old Coleman Wong, 7-6 (7-3) 2-6 7-6 (7-5), the number of American worlds in Ben Shelton, provided the first 20-year-old victory.
American third seed Taylor Fritz was eased by winning Italian Lorenzo Songo 7-6 (7-2) 6-3 to the next round.
