The special genetic profile of the Quebecers plays an important role in certain cardiac diseases, demonstrates a work carried out by the Institute of Montreal Cardiology (ICM).
A quarter of patients tested as part of this study had a certain heart genetic anomaly. In addition, 71% of the participants were at least one parent of the Franco-Canadian ancestor, which was called “an important progress” in understanding the genetic profile of heart disease.
“This builds the genetic reasons for the patient, the patient can guide the treatment of the Cardiovascular Genetics Center of the Institute of Cardiology, Doctor Rafig Tadros.
It is also important that the patient is a legacy of the disease of the patient, and therefore it is also important for the detection of family members with a molecular genetic test and blood test.
Dr Rafik Tadros
The study took place for 14 years and 2,100 patients who had 2,100 patients with darithomyopathicism of arrhythmia or suspicious knowledge.
The Cookek took advantage of the ICM molecular diagnostic laboratory, which has a solid experience in the interpretation of cardiots, and the Cookek, the Cartagene Platform of the Population Cohort (Cag).
This was allowed to have a better interpretation of genetic changes identified in Quebec patients with hereditary heart disease, which was explained by the press release.
Dr. Tadros believes that this investigation is a great progress in the main advantage of the Genetic Factor of Heart Diseases, especially for the FRANKO-Canadian ancestor, especially the form of a very participant. ”
“It is important to know the genetic basis of the French canadian population, because there are certain changes in recurrence,” said Dr. Tadros. It is important to know them, but it is important to compare repetitive genetic options compared to the population cohort or population base. ”
For example, researchers, researchers think that certain options think of heart disease, because in patients often encountered, probably found themselves in the most likely Quebec population.
On the other hand, some options found in patients are very rare in the general population that is suitable for a possible reason.
In these results, he opened the way to the more target selection and patient care, which has a direct effects for preventing and managing hereditary heart disease.
If the relatives of the primary patient are the same genetic mutation, “Cardiology has monitoring, doctor Tadros said. If it is written, because it is something to prevent it.”
Outside the family examination, the results of the study are useful to clear the diagnosis and regulate patient concerns, as an example of heart muscle disease.
“If we take the example of the pattern of the cardiomiopathy, some changes increase the risk of sudden death, the risk of heart catch,” he said, doctor Tadros. Thus, in these patients, a defibrillator tends to be prone to a defibrillator to prevent sudden death compared to another person who has the same clinical presentation but not mutational. ”
Some rare syndromes can imitate the presentation of a cardiomyopathy, whereas a completely different disease, a completely different disease that requires different treatment; A genetic analysis will allow you to make a clear diagnosis here.
If there is no open cause of cardiomyopathy or the reason is not explained in the disease, the doctor said Tadros.
This work confirms the importance of genetics for heart disease and arithmia, and this is the importance of having local experience in genetic analysis because we see that our population is different.
“There is a really important effect in terms of clinical management,” he said, Dr. Tadros. When we look at the spread of some genetic changes in the experienced Canadian-French population, it is important not only to be caused by the population and the cause of a genetic option, but also for family examination, but also to take care of the patient. ”
